Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules

Calreticulin is a lectin chaperone of the endoplasmic reticulum (ER). In calreticulin-deficient cells, major histocompatibility complex (MHC) class I molecules travel to the cell surface in association with a sub-optimal peptide load. Here, we show that calreticulin exits the ER to accumulate in the...

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Detalhes bibliográficos
Main Authors: Howe, Christopher, Garstka, Malgorzata, Al-Balushi, Mohammed, Ghanem, Esther, Antoniou, Antony N, Fritzsche, Susanne, Jankevicius, Gytis, Kontouli, Nasia, Schneeweiss, Clemens, Williams, Anthony, Elliott, Tim, Springer, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790484/
https://ncbi.nlm.nih.gov/pubmed/19851281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.296
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