A Mechanistic Basis for the Co-evolution of Chicken Tapasin and Major Histocompatibility Complex Class I (MHC I) Proteins

MHC class I molecules display peptides at the cell surface to cytotoxic T cells. The co-factor tapasin functions to ensure that MHC I becomes loaded with high affinity peptides. In most mammals, the tapasin gene appears to have little sequence diversity and few alleles and is located distal to sever...

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Main Authors: van Hateren, Andy, Carter, Rachel, Bailey, Alistair, Kontouli, Nasia, Williams, Anthony P., Kaufman, Jim, Elliott, Tim
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3820913/
https://ncbi.nlm.nih.gov/pubmed/24078633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.474031
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