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Inhibition of ischemia-induced angiogenesis by benzo[a]pyrene in a manner dependent on the aryl hydrocarbon receptor

We have investigated the effect of benzo[a]pyrene (B[a]P), a carcinogen of tobacco smoke and an agonist for the aryl hydrocarbon receptor (AHR), on hypoxia-induced angiogenesis. Ischemia was induced by femoral artery ligation in wild-type and AHR-null mice, and the animals were subjected to oral adm...

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Detalhes bibliográficos
Main Authors: Ichihara, Sahoko, Yamada, Yoshiji, Gonzalez, Frank J., Nakajima, Tamie, Murohara, Toyoaki, Ichihara, Gaku
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790146/
https://ncbi.nlm.nih.gov/pubmed/19351592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.01.187
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