The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[a]pyrene

Benzo[a]pyrene (B[a]P) is a ligand for the aryl hydrocarbon receptor (Ahr). After binding ligand, Ahr dimerizes with the aryl hydrocarbon receptor nuclear translocator (Arnt) protein, and the dimer upregulates the transcription of Cyp1a1, Cyp1b1 and other enzymes involved in the metabolic activation...

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Detalhes bibliográficos
Main Authors: Shi, Shengli, Yoon, Diana Y., Hodge-Bell, Kimberly C., Bebenek, Ilona G., Whitekus, Michael J., Zhang, Ruixue, Cochran, Alistair J., Huerta-Yepez, Sara, Yim, Sun-Hee, Gonzalez, Frank J., Jaiswal, Anil K., Hankinson, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Carcinogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791324/
https://ncbi.nlm.nih.gov/pubmed/19755658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgp201
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