The aryl hydrocarbon receptor nuclear translocator (Arnt) is required for tumor initiation by benzo[a]pyrene

Benzo[a]pyrene (B[a]P) is a ligand for the aryl hydrocarbon receptor (Ahr). After binding ligand, Ahr dimerizes with the aryl hydrocarbon receptor nuclear translocator (Arnt) protein, and the dimer upregulates the transcription of Cyp1a1, Cyp1b1 and other enzymes involved in the metabolic activation...

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Dades bibliogràfiques
Autors principals: Shi, Shengli, Yoon, Diana Y., Hodge-Bell, Kimberly C., Bebenek, Ilona G., Whitekus, Michael J., Zhang, Ruixue, Cochran, Alistair J., Huerta-Yepez, Sara, Yim, Sun-Hee, Gonzalez, Frank J., Jaiswal, Anil K., Hankinson, Oliver
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2009
Matèries:
Carcinogenesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791324/
https://ncbi.nlm.nih.gov/pubmed/19755658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgp201
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