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Adaptive strategies of the influenza virus polymerase for replication in humans

Transmission of influenza viruses into the human population requires surmounting barriers to cross-species infection. Changes in the influenza polymerase overcome one such barrier. Viruses isolated from birds generally contain polymerases with the avian-signature glutamic acid at amino acid 627 in t...

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Detalhes bibliográficos
Main Authors: Mehle, Andrew, Doudna, Jennifer A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789757/
https://ncbi.nlm.nih.gov/pubmed/19995968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911915106
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