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Reassortment and Mutation of the Avian Influenza Virus Polymerase PA Subunit Overcome Species Barriers

The emergence of new pandemic influenza A viruses requires overcoming barriers to cross-species transmission as viruses move from animal reservoirs into humans. This complicated process is driven by both individual gene mutations and genome reassortments. The viral polymerase complex, composed of th...

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Main Authors: Mehle, Andrew, Dugan, Vivien G., Taubenberger, Jeffery K., Doudna, Jennifer A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264373/
https://ncbi.nlm.nih.gov/pubmed/22090127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06203-11
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