Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis

The arachidonic acid (AA) cascade produces eicosanoids, such as prostaglandins (PGs), that regulate physiological and pathological functions. Although various nonsteroidal anti-inflammatory drugs have been developed, blocking upstream components (cyclooxygenase-1 and -2) of the AA cascade leads to s...

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Dades bibliogràfiques
Autors principals: Kihara, Yasuyuki, Matsushita, Takuya, Kita, Yoshihiro, Uematsu, Satoshi, Akira, Shizuo, Kira, Jun-ichi, Ishii, Satoshi, Shimizu, Takao
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789753/
https://ncbi.nlm.nih.gov/pubmed/19995978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906891106
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