Farnesoid X Receptor Critically Determines the Fibrotic Response in Mice but Is Expressed to a Low Extent in Human Hepatic Stellate Cells and Periductal Myofibroblasts

The nuclear bile acid receptor, farnesoid X receptor (FXR), may play a pivotal role in liver fibrosis. We tested the impact of genetic FXR ablation in four different mouse models. Hepatic fibrosis was induced in wild-type and FXR knock-out mice (FXR(−/−)) by CCl(4) intoxication, 3,5-diethoxycarbonyl...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Fickert, Peter, Fuchsbichler, Andrea, Moustafa, Tarek, Wagner, Martin, Zollner, Gernot, Halilbasic, Emina, Stöger, Ulrike, Arrese, Marco, Pizarro, Margarita, Solís, Nancy, Carrasco, Gonzalo, Caligiuri, Alessandra, Sombetzki, Martina, Reisinger, Emil, Tsybrovskyy, Oleksiy, Zatloukal, Kurt, Denk, Helmut, Jaeschke, Hartmut, Pinzani, Massimo, Trauner, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2009
Soggetti:
Regular Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789609/
https://ncbi.nlm.nih.gov/pubmed/19910507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.090114
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi