Farnesoid X Receptor Critically Determines the Fibrotic Response in Mice but Is Expressed to a Low Extent in Human Hepatic Stellate Cells and Periductal Myofibroblasts

The nuclear bile acid receptor, farnesoid X receptor (FXR), may play a pivotal role in liver fibrosis. We tested the impact of genetic FXR ablation in four different mouse models. Hepatic fibrosis was induced in wild-type and FXR knock-out mice (FXR(−/−)) by CCl(4) intoxication, 3,5-diethoxycarbonyl...

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Главные авторы: Fickert, Peter, Fuchsbichler, Andrea, Moustafa, Tarek, Wagner, Martin, Zollner, Gernot, Halilbasic, Emina, Stöger, Ulrike, Arrese, Marco, Pizarro, Margarita, Solís, Nancy, Carrasco, Gonzalo, Caligiuri, Alessandra, Sombetzki, Martina, Reisinger, Emil, Tsybrovskyy, Oleksiy, Zatloukal, Kurt, Denk, Helmut, Jaeschke, Hartmut, Pinzani, Massimo, Trauner, Michael
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Investigative Pathology 2009
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Regular Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789609/
https://ncbi.nlm.nih.gov/pubmed/19910507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.090114
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