Activin Signaling in Microsatellite Stable Colon Cancers Is Disrupted by a Combination of Genetic and Epigenetic Mechanisms

BACKGROUND: Activin receptor 2 (ACVR2) is commonly mutated in microsatellite unstable (MSI) colon cancers, leading to protein loss, signaling disruption, and larger tumors. Here, we examined activin signaling disruption in microsatellite stable (MSS) colon cancers. METHODS: Fifty-one population-base...

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Detalhes bibliográficos
Main Authors: Jung, Barbara, Gomez, Jessica, Chau, Eddy, Cabral, Jennifer, Lee, Jeffrey K., Anselm, Aimee, Slowik, Przemyslaw, Ream-Robinson, Deena, Messer, Karen, Sporn, Judith, Shin, Sung K., Boland, C. Richard, Goel, Ajay, Carethers, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789408/
https://ncbi.nlm.nih.gov/pubmed/20011542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008308
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