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The structural basis of pregnane X receptor binding promiscuity
The steroid and xenobiotic-responsive human pregnane X receptor (PXR) binds a broad range of structurally diverse compounds. The structures of the apo and ligand-bound forms of PXR are very similar, in contrast to most promiscuous proteins that generally adapt their shape to different ligands. We in...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2789303/ https://ncbi.nlm.nih.gov/pubmed/19856963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901578n |
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