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Significant speedup of database searches with HMMs by search space reduction with PSSM family models
Motivation: Profile hidden Markov models (pHMMs) are currently the most popular modeling concept for protein families. They provide sensitive family descriptors, and sequence database searching with pHMMs has become a standard task in today's genome annotation pipelines. On the downside, search...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2788931/ https://ncbi.nlm.nih.gov/pubmed/19828575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btp593 |
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