Common Mechanistic Features among Metallo-β-lactamases: A COMPUTATIONAL STUDY OF AEROMONAS HYDROPHILA CphA ENZYME

Metallo-β-lactamases (MβLs) constitute an increasingly serious clinical threat by giving rise to β-lactam antibiotic resistance. They accommodate in their catalytic pocket one or two zinc ions, which are responsible for the hydrolysis of β-lactams. Recent x-ray studies on a member of the mono-zinc B...

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Bibliographic Details
Main Authors: Simona, Fabio, Magistrato, Alessandra, Dal Peraro, Matteo, Cavalli, Andrea, Vila, Alejandro J., Carloni, Paolo
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Enzyme Catalysis and Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788867/
https://ncbi.nlm.nih.gov/pubmed/19671702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.049502
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