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Common Mechanistic Features among Metallo-β-lactamases: A COMPUTATIONAL STUDY OF AEROMONAS HYDROPHILA CphA ENZYME
Metallo-β-lactamases (MβLs) constitute an increasingly serious clinical threat by giving rise to β-lactam antibiotic resistance. They accommodate in their catalytic pocket one or two zinc ions, which are responsible for the hydrolysis of β-lactams. Recent x-ray studies on a member of the mono-zinc B...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society for Biochemistry and Molecular Biology
2009
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2788867/ https://ncbi.nlm.nih.gov/pubmed/19671702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.049502 |
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