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Common Mechanistic Features among Metallo-β-lactamases: A COMPUTATIONAL STUDY OF AEROMONAS HYDROPHILA CphA ENZYME
Metallo-β-lactamases (MβLs) constitute an increasingly serious clinical threat by giving rise to β-lactam antibiotic resistance. They accommodate in their catalytic pocket one or two zinc ions, which are responsible for the hydrolysis of β-lactams. Recent x-ray studies on a member of the mono-zinc B...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2788867/ https://ncbi.nlm.nih.gov/pubmed/19671702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.049502 |
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