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Downregulation of Neutral Ceramidase by Gemcitabine: Implications for Cell Cycle Regulation

Gemcitabine (GMZ) is a chemotherapeutic agent with well established effects on cell growth arrest and apoptosis. In this study, we investigated the potential roles of bioactive sphingolipids in mediating the growth suppressing effects of GMZ on a polyoma middle T transformed murine endothelial cell...

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Main Authors: Wu, Bill X., Zeidan, Youssef H., Hannun, Yusuf A.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788435/
https://ncbi.nlm.nih.gov/pubmed/19345744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2009.03.012
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