Mixed Lineage Kinase 3 negatively regulates IKK activity and enhances etoposide-induced cell death

Mixed Lineage Kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase (MAP3K) that activates multiple MAPK signaling pathways. Nuclear factor kappa B (NF-κB) is a transcription factor that has important functions in inflammation, immunity and cell survival. We found that silencing mlk3 e...

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Bibliographic Details
Main Authors: Cole, Eric T., Zhan, Yu, Abi Saab, Widian F., Korchnak, Amanda C., Ashburner, Brian P., Chadee, Deborah N.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788010/
https://ncbi.nlm.nih.gov/pubmed/19782705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2009.09.014
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