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Connecting synthetic chemistry decisions to cell and genome biology using small-molecule phenotypic profiling
Discovering small-molecule modulators for thousands of gene products requires multiple stages of biological testing, specificity evaluation, and chemical optimization. Many cellular profiling methods, including cellular sensitivity, gene-expression, and cellular imaging, have emerged as methods to a...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2787914/ https://ncbi.nlm.nih.gov/pubmed/19825513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2009.09.018 |
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