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ATP Induced Conformational Changes in Hsp70: Molecular Dynamics and Experimental Validation of an In Silico Predicted Conformation

The 70-kD heat shock proteins (Hsp70s) play important roles in preventing the misfolding of proteins and repairing damage under stress by coupling ATP binding and hydrolysis to protein substrate release and binding, respectively. ATP binding is believed to induce closing of the Hsp70 nucleotide bind...

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Detalhes bibliográficos
Main Authors: Woo, Hyung-June, Jiang, Jianwen, Lafer, Eileen M., Sousa, Rui
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787669/
https://ncbi.nlm.nih.gov/pubmed/19883127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901256y
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