Immunization by influenza virus-like particles protects aged mice against lethal influenza virus challenge

Influenza virus-like particles (VLPs) were produced in Sf9 insect cells by co-expressing the matrix protein M1 and the surface glycoproteins hemagglutinin (HA) and neuraminidase (NA) using the recombinant baculovirus expression system. The VLPs were morphologically similar to influenza virions. Both...

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Bibliographic Details
Main Authors: Wen, Zhiyuan, Ye, Ling, Gao, Yulong, Pan, Lei, Dong, Ke, Bu, Zhigao, Compans, Richard W., Yang, Chinglai
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787645/
https://ncbi.nlm.nih.gov/pubmed/19772876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2009.09.005
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