Toward the Discovery of Vaccine Adjuvants: Coupling In Silico Screening and In Vitro Analysis of Antagonist Binding to Human and Mouse CCR4 Receptors

BACKGROUND: Adjuvants enhance or modify an immune response that is made to an antigen. An antagonist of the chemokine CCR4 receptor can display adjuvant-like properties by diminishing the ability of CD4+CD25+ regulatory T cells (Tregs) to down-regulate immune responses. METHODOLOGY: Here, we have us...

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Detalhes bibliográficos
Main Authors: Davies, Matthew N., Bayry, Jagadeesh, Tchilian, Elma Z., Vani, Janakiraman, Shaila, Melkote S., Forbes, Emily K., Draper, Simon J., Beverley, Peter C. L., Tough, David F., Flower, Darren R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787246/
https://ncbi.nlm.nih.gov/pubmed/20011659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008084
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