Discovery of a Potent and Orally Bioavailable CCR2 and CCR5 Dual Antagonist

[Image: see text] This report describes the discovery of a potent, orally bioavailable CC chemokine receptor 2 (CCR2) antagonist which, while optimized for CCR2 potency, also had potent CC chemokine receptor 5 (CCR5) activity.

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Bibliographic Details
Main Authors: Pasternak, Alexander, Goble, Stephen D., Struthers, Mary, Vicario, Pasquale P., Ayala, Julia M., Di Salvo, Jerry, Kilburn, Ruth, Wisniewski, Thomas, DeMartino, Julie A., Mills, Sander G., Yang, Lihu
Format: Artigo
Language:Inglês
Published: American Chemical Society 2009
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007850/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml900009d
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