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Computational design of Candida boidinii xylose reductase for altered cofactor specificity
In this study we introduce a computationally-driven enzyme redesign workflow for altering cofactor specificity from NADPH to NADH. By compiling and comparing data from previous studies involving cofactor switching mutations, we show that their effect cannot be explained as straightforward changes in...
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| Huvudupphovsmän: | , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Wiley Subscription Services, Inc., A Wiley Company
2009
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2786976/ https://ncbi.nlm.nih.gov/pubmed/19693930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.227 |
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