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Computational design of Candida boidinii xylose reductase for altered cofactor specificity

In this study we introduce a computationally-driven enzyme redesign workflow for altering cofactor specificity from NADPH to NADH. By compiling and comparing data from previous studies involving cofactor switching mutations, we show that their effect cannot be explained as straightforward changes in...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Khoury, George A, Fazelinia, Hossein, Chin, Jonathan W, Pantazes, Robert J, Cirino, Patrick C, Maranas, Costas D
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Wiley Subscription Services, Inc., A Wiley Company 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786976/
https://ncbi.nlm.nih.gov/pubmed/19693930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.227
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