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Computational design of Candida boidinii xylose reductase for altered cofactor specificity
In this study we introduce a computationally-driven enzyme redesign workflow for altering cofactor specificity from NADPH to NADH. By compiling and comparing data from previous studies involving cofactor switching mutations, we show that their effect cannot be explained as straightforward changes in...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Wiley Subscription Services, Inc., A Wiley Company
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2786976/ https://ncbi.nlm.nih.gov/pubmed/19693930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.227 |
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