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Extending Iterative Protein Redesign and Optimization (IPRO) in Protein Library Design for Ligand Specificity
In this article we extend the Iterative Protein Redesign and Optimization (IPRO) framework for the design of protein libraries with targeted ligand specificity. Mutations that minimize the binding energy with the desired ligand are identified. At the same time explicit constraints are introduced tha...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Biophysical Society
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1861794/ https://ncbi.nlm.nih.gov/pubmed/17208966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.096016 |
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