Alternative Splicing Modulates Autoinhibition and SH3 Accessibility in the Src Kinase Fyn

Src family kinases are central regulators of a large number of signaling pathways. To adapt to the idiosyncrasies of different cell types, these kinases may need a fine-tuning of their intrinsic molecular control mechanisms. Here, we describe on a molecular level how the Fyn kinase uses alternative...

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Main Authors: Brignatz, C., Paronetto, M. P., Opi, S., Cappellari, M., Audebert, S., Feuillet, V., Bismuth, G., Roche, S., Arold, S. T., Sette, C., Collette, Y.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786882/
https://ncbi.nlm.nih.gov/pubmed/19805512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00398-09
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