Semliki Forest Virus Expressing Interleukin-12 Induces Antiviral and Antitumoral Responses in Woodchucks with Chronic Viral Hepatitis and Hepatocellular Carcinoma

A vector based on Semliki Forest virus (SFV) expressing high levels of interleukin-12 (SFV-enhIL-12) has previously demonstrated potent antitumoral efficacy in small rodents with hepatocellular carcinoma (HCC) induced by transplantation of tumor cells. In the present study, the infectivity and antit...

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Autors principals: Rodriguez-Madoz, Juan R., Liu, Katherine H., Quetglas, Jose I., Ruiz-Guillen, Marta, Otano, Itziar, Crettaz, Julien, Butler, Scott D., Bellezza, Christine A., Dykes, Nathan L., Tennant, Bud C., Prieto, Jesus, González-Aseguinolaza, Gloria, Smerdou, Cristian, Menne, Stephan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786746/
https://ncbi.nlm.nih.gov/pubmed/19740992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01597-09
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