Antiviral Effect of Orally Administered (−)-β-d-2-Aminopurine Dioxolane in Woodchucks with Chronic Woodchuck Hepatitis Virus Infection

(−)-β-d-2-Aminopurine dioxolane (APD) is a nucleoside prodrug that is efficiently converted to 9-(β-d-1,3-dioxolan-4-yl)guanine (DXG). DXG has antiviral activity in vitro against hepatitis B virus (HBV) but limited aqueous solubility, making it difficult to administer orally to HBV-infected individu...

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Autori principali: Menne, Stephan, Asif, Ghazia, Narayanasamy, Jannan, Butler, Scott D., George, Andrea L., Hurwitz, Selwyn J., Schinazi, Raymond F., Chu, Chung K., Cote, Paul J., Gerin, John L., Tennant, Bud C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2007
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043196/
https://ncbi.nlm.nih.gov/pubmed/17606676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00325-07
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