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Role of Plasmodium falciparum Digestive Vacuole Plasmepsins in the Specificity and Antimalarial Mode of Action of Cysteine and Aspartic Protease Inhibitors

Hemoglobin (Hb) degradation is essential for the growth of the intraerythrocytic stages of malarial parasites. This process, which occurs inside an acidic digestive vacuole (DV), is thought to involve the action of four aspartic proteases, termed plasmepsins (PMs). These enzymes have received consid...

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Bibliografski detalji
Glavni autori: Moura, Pedro A., Dame, John B., Fidock, David A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786340/
https://ncbi.nlm.nih.gov/pubmed/19752273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00882-09
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