New Class of Small Nonpeptidyl Compounds Blocks Plasmodium falciparum Development In Vitro by Inhibiting Plasmepsins

Malarial parasites rely on aspartic proteases called plasmepsins to digest hemoglobin during the intraerythrocytic stage. Plasmepsins from Plasmodium falciparum and Plasmodium vivax have been cloned and expressed for a variety of structural and enzymatic studies. Recombinant plasmepsins possess kine...

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Detalhes bibliográficos
Main Authors: Jiang, Suping, Prigge, Sean T., Wei, Lan, Gao, Yu-e, Hudson, Thomas H., Gerena, Lucia, Dame, John B., Kyle, Dennis E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC90695/
https://ncbi.nlm.nih.gov/pubmed/11502532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.9.2577-2584.2001
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