New Class of Small Nonpeptidyl Compounds Blocks Plasmodium falciparum Development In Vitro by Inhibiting Plasmepsins

Malarial parasites rely on aspartic proteases called plasmepsins to digest hemoglobin during the intraerythrocytic stage. Plasmepsins from Plasmodium falciparum and Plasmodium vivax have been cloned and expressed for a variety of structural and enzymatic studies. Recombinant plasmepsins possess kine...

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Main Authors: Jiang, Suping, Prigge, Sean T., Wei, Lan, Gao, Yu-e, Hudson, Thomas H., Gerena, Lucia, Dame, John B., Kyle, Dennis E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
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Mechanisms of Action: Physiological Effects
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC90695/
https://ncbi.nlm.nih.gov/pubmed/11502532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.9.2577-2584.2001
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