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Knowledge-based Characterization of Similarity Relationships in the Human Protein-Tyrosine Phosphatase Family for Rational Inhibitor Design

Tyrosine phosphorylation, controlled by the coordinated action of protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs), is a fundamental regulatory mechanism of numerous physiological processes. PTPs are implicated in a number of human diseases and their potential as prospective...

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Bibliografiske detaljer
Main Authors: Vidović, Dušica, Schürer, Stephan C.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786264/
https://ncbi.nlm.nih.gov/pubmed/19810703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9008899
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