Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase

We report here a class of thiazolidine-2,4-diones and 2-thioxothiazolidin-4-ones as potent inhibitors of the lymphoid specific tyrosine phosphatase (Lyp) identified from high throughput screens. Chemical modification by incorporating known phosphotyrosine (pTyr) mimics led to discovery of a salicyla...

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Detalles Bibliográficos
Autores principales: Xie, Yuli, Liu, Yidong, Gong, Gangli, Rinderspacher, Alison, Deng, Shi-Xian, Smith, Deborah H., Toebben, Udo, Tzilianos, Effie, Branden, Lars, Vidović, Dušica, Chung, Caty, Schürer, Stephan, Tautz, Lutz, Landry, Donald W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701911/
https://ncbi.nlm.nih.gov/pubmed/18434147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.03.079
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