Notch2 Signaling Sensitizes Endothelial Cells to Apoptosis by Negatively Regulating the Key Protective Molecule Survivin

BACKGROUND: Notch signaling pathway controls key functions in vascular and endothelial cells (ECs) where Notch4 plays a major role. However, little is known about the contribution of other Notch receptors. This study investigated regulation of Notch2 and further examined its implication in EC dysfun...

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Bibliographic Details
Main Authors: Quillard, Thibaut, Devalliere, Julie, Chatelais, Mathias, Coulon, Flora, Séveno, Céline, Romagnoli, Mathilde, Barillé Nion, Sophie, Charreau, Béatrice
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785888/
https://ncbi.nlm.nih.gov/pubmed/20011512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008244
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