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Effect of Thioredoxin Deletion and p53 Cysteine Replacement on Human p53 Activity in Wild-type and Thioredoxin Reductase Null Yeast
Reporter gene transactivation by human p53 is inhibited in budding yeast lacking the TRR1 gene encoding thioredoxin reductase. To investigate the role of thioredoxin in controlling p53 activity, the level of reporter gene transactivation by p53 was determined in yeast lacking the TRX1 and TRX2 genes...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2009
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2785850/ https://ncbi.nlm.nih.gov/pubmed/19681600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900757q |
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