A Novel Protein Associated with Membrane-type 1 Matrix Metalloproteinase Binds p27(kip1) and Regulates RhoA Activation, Actin Remodeling, and Matrigel Invasion

Pericellular proteolysis by membrane-type 1 matrix metalloproteinase (MT1-MMP) plays a pivotal role in tumor cell invasion. Localization of MT1-MMP at the invasion front of cells, e.g. on lamellipodia and invadopodia, has to be regulated in coordination with reorganization of the actin cytoskeleton....

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Bibliographic Details
Main Authors: Hoshino, Daisuke, Tomari, Taizo, Nagano, Makoto, Koshikawa, Naohiko, Seiki, Motoharu
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Molecular Basis of Cell and Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785659/
https://ncbi.nlm.nih.gov/pubmed/19654316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.041400
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