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A Novel Protein Associated with Membrane-type 1 Matrix Metalloproteinase Binds p27(kip1) and Regulates RhoA Activation, Actin Remodeling, and Matrigel Invasion
Pericellular proteolysis by membrane-type 1 matrix metalloproteinase (MT1-MMP) plays a pivotal role in tumor cell invasion. Localization of MT1-MMP at the invasion front of cells, e.g. on lamellipodia and invadopodia, has to be regulated in coordination with reorganization of the actin cytoskeleton....
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2785659/ https://ncbi.nlm.nih.gov/pubmed/19654316 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.041400 |
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