Homologous Recombination but Not Nucleotide Excision Repair Plays a Pivotal Role in Tolerance of DNA-Protein Cross-links in Mammalian Cells

DNA-protein cross-links (DPCs) are unique among DNA lesions in their unusually bulky nature. The steric hindrance imposed by cross-linked proteins (CLPs) will hamper DNA transactions, such as replication and transcription, posing an enormous threat to cells. In bacteria, DPCs with small CLPs are eli...

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Autori principali: Nakano, Toshiaki, Katafuchi, Atsushi, Matsubara, Mayumi, Terato, Hiroaki, Tsuboi, Tomohiro, Masuda, Tasuku, Tatsumoto, Takahiro, Pack, Seung Pil, Makino, Keisuke, Croteau, Deborah L., Van Houten, Bennett, Iijima, Kenta, Tauchi, Hiroshi, Ide, Hiroshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
Soggetti:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785636/
https://ncbi.nlm.nih.gov/pubmed/19674975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.019174
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