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Repair activity of base and nucleotide excision repair enzymes for guanine lesions induced by nitrosative stress
Nitric oxide (NO) induces deamination of guanine, yielding xanthine and oxanine (Oxa). Furthermore, Oxa reacts with polyamines and DNA binding proteins to form cross-link adducts. Thus, it is of interest how these lesions are processed by DNA repair enzymes in view of the genotoxic mechanism of NO....
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1079971/ https://ncbi.nlm.nih.gov/pubmed/15831791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki513 |
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