Repair activity of base and nucleotide excision repair enzymes for guanine lesions induced by nitrosative stress

Nitric oxide (NO) induces deamination of guanine, yielding xanthine and oxanine (Oxa). Furthermore, Oxa reacts with polyamines and DNA binding proteins to form cross-link adducts. Thus, it is of interest how these lesions are processed by DNA repair enzymes in view of the genotoxic mechanism of NO....

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Main Authors: Nakano, Toshiaki, Katafuchi, Atsushi, Shimizu, Ryoko, Terato, Hiroaki, Suzuki, Toshinori, Tauchi, Hiroshi, Makino, Keisuke, Skorvaga, Milan, Van Houten, Bennett, Ide, Hiroshi
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2005
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1079971/
https://ncbi.nlm.nih.gov/pubmed/15831791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki513
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