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ROCK Mediates Phorbol Ester-induced Apoptosis in Prostate Cancer Cells via p21(Cip1) Up-regulation and JNK
It is established that androgen-dependent prostate cancer cells undergo apoptosis upon treatment with phorbol esters and related analogs, an effect primarily mediated by PKCδ. Treatment of LNCaP prostate cancer cells with phorbol 12-myristate 13-acetate (PMA) causes a strong and sustained activation...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2785568/ https://ncbi.nlm.nih.gov/pubmed/19667069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.007971 |
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