Identification and Functional Characterization of Cytoplasmic Determinants of Plasmid DNA Nuclear Import

Import of exogenous plasmid DNA (pDNA) into mammalian cell nuclei represents a key intracellular obstacle to efficient non-viral gene delivery. This includes access of the pDNA to the nuclei of non-dividing cells where the presence of an intact nuclear membrane is limiting for gene transfer. Here we...

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Main Authors: Munkonge, Felix M., Amin, Vaksha, Hyde, Stephen C., Green, Anne-Marie, Pringle, Ian A., Gill, Deborah R., Smith, Joel W. S., Hooley, Robert P., Xenariou, Stefania, Ward, Malcolm A., Leeds, Nicola, Leung, Kit-Yi, Chan, Mario, Hillery, Elizabeth, Geddes, Duncan M., Griesenbach, Uta, Postel, Edith H., Dean, David A., Dunn, Michael J., Alton, Eric W. F. W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785383/
https://ncbi.nlm.nih.gov/pubmed/19638341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.034850
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