Structure of the Plasmodium falciparum Circumsporozoite Protein, a Leading Malaria Vaccine Candidate

The Plasmodium falciparum circumsporozoite protein (CSP) is critical for sporozoite function and invasion of hepatocytes. Given its critical nature, a phase III human CSP malaria vaccine trial is ongoing. The CSP is composed of three regions as follows: an N terminus that binds heparin sulfate prote...

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Bibliografski detalji
Glavni autori: Plassmeyer, Matthew L., Reiter, Karine, Shimp, Richard L., Kotova, Svetlana, Smith, Paul D., Hurt, Darrell E., House, Brent, Zou, Xiaoyan, Zhang, Yanling, Hickman, Merrit, Uchime, Onyinyechukwu, Herrera, Raul, Nguyen, Vu, Glen, Jacqueline, Lebowitz, Jacob, Jin, Albert J., Miller, Louis H., MacDonald, Nicholas J., Wu, Yimin, Narum, David L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Protein Structure and Folding
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785382/
https://ncbi.nlm.nih.gov/pubmed/19633296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.013706
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