Structure of the Plasmodium falciparum Circumsporozoite Protein, a Leading Malaria Vaccine Candidate

The Plasmodium falciparum circumsporozoite protein (CSP) is critical for sporozoite function and invasion of hepatocytes. Given its critical nature, a phase III human CSP malaria vaccine trial is ongoing. The CSP is composed of three regions as follows: an N terminus that binds heparin sulfate prote...

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Detalhes bibliográficos
Main Authors: Plassmeyer, Matthew L., Reiter, Karine, Shimp, Richard L., Kotova, Svetlana, Smith, Paul D., Hurt, Darrell E., House, Brent, Zou, Xiaoyan, Zhang, Yanling, Hickman, Merrit, Uchime, Onyinyechukwu, Herrera, Raul, Nguyen, Vu, Glen, Jacqueline, Lebowitz, Jacob, Jin, Albert J., Miller, Louis H., MacDonald, Nicholas J., Wu, Yimin, Narum, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785382/
https://ncbi.nlm.nih.gov/pubmed/19633296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.013706
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