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Engineering a Ubiquitin Ligase Reveals Conformational Flexibility Required for Ubiquitin Transfer
Protein ubiquitination regulates numerous cellular functions in eukaryotes. The prevailing view about the role of RING or U-box ubiquitin ligases (E3) is to provide precise positioning between the attached substrate and the ubiquitin-conjugating enzyme (E2). However, the mechanism of ubiquitin trans...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2785368/ https://ncbi.nlm.nih.gov/pubmed/19648119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.032334 |
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