Purification and Functional Reconstitution of Monomeric μ-Opioid Receptors: ALLOSTERIC MODULATION OF AGONIST BINDING BY G(i2)

Despite extensive characterization of the μ-opioid receptor (MOR), the biochemical properties of the isolated receptor remain unclear. In light of recent reports, we proposed that the monomeric form of MOR can activate G proteins and be subject to allosteric regulation. A μ-opioid receptor fused to...

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Библиографические подробности
Главные авторы: Kuszak, Adam J., Pitchiaya, Sethuramasundaram, Anand, Jessica P., Mosberg, Henry I., Walter, Nils G., Sunahara, Roger K.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2009
Предметы:
Mechanisms of Signal Transduction
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785361/
https://ncbi.nlm.nih.gov/pubmed/19542234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.026922
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