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Numb Regulates Post-endocytic Trafficking and Degradation of Notch1

Notch is a transmembrane receptor that controls cell fate decisions during development and tissue homeostasis. Both activation and attenuation of the Notch signal are tightly regulated by endocytosis. The adaptor protein Numb acts as an inhibitor of Notch and is known to function within the intracel...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: McGill, Melanie A., Dho, Sascha E., Weinmaster, Gerry, McGlade, C. Jane
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785331/
https://ncbi.nlm.nih.gov/pubmed/19567869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.014845
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