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Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation
Failure of trabecular myocytes to undergo appropriate cell cycle withdrawal leads to ventricular noncompaction and heart failure. Signaling of growth factor receptor ERBB2 is critical for myocyte proliferation and trabeculation. However, the mechanisms underlying appropriate downregulation of trabec...
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| Pubblicato in: | J Clin Invest |
|---|---|
| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5272190/ https://ncbi.nlm.nih.gov/pubmed/28067668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI91081 |
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