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NUMB and NUMBL differences in gene regulation
NUMB, and its close homologue NUMBL, behave as tumor suppressor genes by regulating the Notch pathway. The downregulation of these genes in tumors is common, allowing aberrant Notch pathway activation and tumor progression. However, some known differences between NUMB and NUMBL have raised unanswere...
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| Publicat a: | Oncotarget |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Impact Journals LLC
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5823667/ https://ncbi.nlm.nih.gov/pubmed/29507685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24186 |
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