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Numb Regulates Post-endocytic Trafficking and Degradation of Notch1
Notch is a transmembrane receptor that controls cell fate decisions during development and tissue homeostasis. Both activation and attenuation of the Notch signal are tightly regulated by endocytosis. The adaptor protein Numb acts as an inhibitor of Notch and is known to function within the intracel...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2785331/ https://ncbi.nlm.nih.gov/pubmed/19567869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.014845 |
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