New Activation Modus of STAT3: A TYROSINE-LESS REGION OF THE INTERLEUKIN-22 RECEPTOR RECRUITS STAT3 BY INTERACTING WITH ITS COILED-COIL DOMAIN

Activation of STAT proteins by cytokines is initiated by their Src homology 2 domain-mediated association with phosphotyrosine residues from the cytoplasmic domain of a receptor. Here, we show that the C terminus of the interleukin-22 receptor (IL-22R) recruits in a tyrosine-independent manner the c...

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Bibliographic Details
Main Authors: Dumoutier, Laure, de Meester, Carole, Tavernier, Jan, Renauld, Jean-Christophe
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785325/
https://ncbi.nlm.nih.gov/pubmed/19632985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.007955
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