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Overexpression of the chromosomally encoded aminoglycoside acetyltransferase eis confers kanamycin resistance in Mycobacterium tuberculosis

The emergence of multidrug-resistant (MDR) tuberculosis (TB) highlights the urgent need to understand the mechanisms of resistance to the drugs used to treat this disease. The aminoglycosides kanamycin and amikacin are important bactericidal drugs used to treat MDR TB, and resistance to one or both...

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Main Authors: Zaunbrecher, M. Analise, Sikes, R. David, Metchock, Beverly, Shinnick, Thomas M., Posey, James E.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785282/
https://ncbi.nlm.nih.gov/pubmed/19906990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907925106
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